Dr Gregory Redpath

Dr Gregory Redpath

Lecturer
  • Ph.D. Medicine                                                                                                              Feb 2011- Aug 2015

Department of Child and Adolescent Health, University of Sydney, Sydney, Australia

  • B.Sc. (Hons.) Biochemistry                                                                                           Feb 2007- Dec 2010

Department of Biochemistry, University of Otago, Dunedin, New Zealand

Medicine & Health
School of Biomedical Sciences

Dr Gregory Redpath is an Associate Group Leader in the Department of Molecular Medicine in the School of Biomedical Sciences. His research focusses on the cell biology of receptor trafficking and its role in serotonin receptor signalling in cardiovascular disease, depression, and anxiety. Dr Redpath undertook his Bachelor of Science (Honours) in the Department of Biochemistry, University of Otago (2007-2010), and PhD at the University of Sydney (2011-2016). Following, he has undertaken postdoctoral position at the University of New South Wales and University of Otago, building a track record in developing advanced live cell imaging techniques to dissect the mechanisms of how cellular processes underpin our health. Dr Redpath's current research aims to uncover how psychedelics act at the molecular level to lead to better treatments for depression and anxiety, identifying the therapeutic potential of psilocybin-related compounds sourced from mushrooms, investigating how serotonin signalling intersects with development of cardiovascular disease, and to work in consultation with First Nations communities to integrate culturally guided molecular research to generate meaningful data and outcomes for these communities.

  • Journal articles | 2025
    Deo N; Siddiqui H; Peppercorn K; Madani G; Rutherford-Blyth A; Rutledge M; Williams MJA; McCormick SPA; Redpath GMI, 2025, 'Antidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding', Journal of Lipid Research, 66, http://dx.doi.org/10.1016/j.jlr.2025.100889
    Journal articles | 2025
    Kim DH; Boby SE; Redpath GMI; Ananthanarayanan V, 2025, 'Driving cancer: Motor and adaptor protein dysregulation in endocytic receptor signalling', Current Opinion in Cell Biology, 97, http://dx.doi.org/10.1016/j.ceb.2025.102598
    Journal articles | 2024
    Tillu VA; Redpath GMI; Rae J; Ruan J; Yao Y; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, 2024, 'Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles', Journal of Cell Science, 137, http://dx.doi.org/10.1242/jcs.262163
    Journal articles | 2024
    Tirumala NA; Redpath GMI; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Vijay Kumar K; Ananthanarayanan V, 2024, 'Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202210026
    Journal articles | 2023
    Redpath GMI; Ananthanarayanan V, 2023, 'Endosomal sorting sorted – motors, adaptors and lessons from in vitro and cellular studies', Journal of Cell Science, 136, http://dx.doi.org/10.1242/jcs.260749
    Journal articles | 2023
    Siddiqui H; Deo N; Rutledge MT; Williams MJA; Redpath GMI; Mccormick SPA, 2023, 'Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis', Arteriosclerosis Thrombosis and Vascular Biology, 43, pp. 1851 - 1866, http://dx.doi.org/10.1161/ATVBAHA.123.319344
    Journal articles | 2022
    Deo N; Redpath G, 2022, 'Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety', Frontiers in Cellular Neuroscience, 15, http://dx.doi.org/10.3389/fncel.2021.804592
    Journal articles | 2022
    Ecker M; Schregle R; Kapoor-Kaushik N; Rossatti P; Betzler VM; Kempe D; Biro M; Ariotti N; Redpath GMI; Rossy J, 2022, 'SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling', Elife, 11, http://dx.doi.org/10.7554/eLife.67550
    Journal articles | 2022
    Redpath G; Deo N, 2022, 'Serotonin: An overlooked regulator of endocytosis and endosomal sorting?', Biology Open, 11, http://dx.doi.org/10.1242/bio.059057
    Journal articles | 2022
    Rossatti P; Redpath GMI; Ziegler L; Samson GPB; Clamagirand CD; Legler DF; Rossy J, 2022, 'Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation', BMC Biology, 20, http://dx.doi.org/10.1186/s12915-022-01386-0
    Journal articles | 2022
    Tirumala NA; Redpath G; Kapoor-Kaushik N; Ariotti N; Dolai P; Kumar KV; Ananthanarayanan V, 2022, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture', BIOPHYSICAL JOURNAL, 121, pp. 1 - 1, http://dx.doi.org/10.1016/j.bpj.2021.11.2703
    Journal articles | 2022
    2022, 'Future leader to watch - Gregory Redpath', BIOLOGY OPEN, 11, http://dx.doi.org/10.1242/bio.059203
    Journal articles | 2021
    Ecker M; Redpath GMI; Nicovich PR; Rossy J, 2021, 'Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins', Molecular Biology of the Cell, 32, pp. 892 - 902, http://dx.doi.org/10.1091/MBC.E20-10-0669
    Journal articles | 2021
    Redpath GMI; Deo N; Siddiqui H; Madani G; Kapoor-Kaushik N; Ariotti N; Rutledge M; Williams MJA; McCormick SPA, 2021, 'Serotonin and common antidepressants regulate lipoprotein(a) macropinocytosis via enhanced cell surface binding', , http://dx.doi.org/10.1101/2021.03.26.437114
    Journal articles | 2021
    Tirumala NA; Redpath G; Skerhut SV; Dolai P; Kapoor-Kaushik N; Ariotti N; Kumar V; Ananthanarayanan V, 2021, 'Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo movement', , http://dx.doi.org/10.1101/2021.04.05.438428
    Journal articles | 2020
    Redpath GMI; Betzler VM; Rossatti P; Rossy J, 2020, 'Membrane Heterogeneity Controls Cellular Endocytic Trafficking', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00757
    Journal articles | 2019
    Redpath GMI; Ecker M; Kapoor-Kaushik N; Vartoukian H; Carnell M; Kempe D; Biro M; Ariotti N; Rossy J; Kaushik N, 2019, 'Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis', Nature Communications, 10, pp. 4392, http://dx.doi.org/10.1038/s41467-019-12352-w
    Journal articles | 2018
    Compeer EB; Kraus F; Ecker M; Redpath G; Amiezer M; Rother N; Nicovich PR; Kapoor-Kaushik N; Deng Q; Samson GPB; Yang Z; Lou J; Carnell M; Vartoukian H; Gaus K; Rossy J, 2018, 'A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-04088-w
    Journal articles | 2017
    Piper AK; Ross SE; Redpath GM; Lemckert FA; Woolger N; Bournazos A; Greer PA; Sutton RB; Cooper ST, 2017, 'Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling', Cellular Signalling, 33, pp. 30 - 40, http://dx.doi.org/10.1016/j.cellsig.2017.02.009
    Journal articles | 2017
    Sharma M; Redpath GM; Williams MJA; McCormick SPA, 2017, 'Recycling of apolipoprotein(a) after PlgRKT-mediated endocytosis of lipoprotein(a)', Circulation Research, 120, pp. 1091 - 1102, http://dx.doi.org/10.1161/CIRCRESAHA.116.310272
    Journal articles | 2016
    Redpath GMI; Sophocleous RA; Turnbull L; Whitchurch CB; Cooper ST, 2016, 'Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins', Traffic, 17, pp. 245 - 266, http://dx.doi.org/10.1111/tra.12370
    Journal articles | 2016
    Sharma M; Redpath G; McCormick S, 2016, 'Calcium dependent endocytosis and recycling of lipoprotein(a) in HepG2 cells', Atherosclerosis, 252, pp. e244 - e244, http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.038
    Journal articles | 2014
    Fuson K; Rice A; Mahling R; Snow A; Nayak K; Shanbhogue P; Meyer AG; Redpath GMI; Hinderliter A; Cooper ST; Sutton RB, 2014, 'Alternate splicing of dysferlin C2A confers Ca2+-dependent and Ca2+-independent binding for membrane repair', Structure, 22, pp. 104 - 115, http://dx.doi.org/10.1016/j.str.2013.10.001
    Journal articles | 2014
    Redpath GMI; Woolger N; Piper AK; Lemckert FA; Lek A; Greer PA; North KN; Cooper ST, 2014, 'Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair', Molecular Biology of the Cell, 25, pp. 3037 - 3048, http://dx.doi.org/10.1091/mbc.E14-04-0947
    Journal articles | 2013
    Lek A; Evesson FJ; Lemckert FA; Redpath GMI; Lueders AK; Turnbull L; Whitchurch CB; North KN; Cooper ST, 2013, 'Calpains, cleaved mini-dysferlinc72, and L-type channels underpin calcium-dependent muscle membrane repair', Journal of Neuroscience, 33, pp. 5085 - 5094, http://dx.doi.org/10.1523/JNEUROSCI.3560-12.2013
  • Conference Papers | 2019
    Monserrat-Martinez A; Redpath G; Govendir MA; O'Carroll A; Murillo ADA; Sierecki E; Gambin Y, 2019, 'Enteropathogenic E. coli Hijacks Programmed Host-Cell Death Pathways by Interfering with the Higher Order Oligomerization of Immune System Proteins', in FASEB JOURNAL, WILEY, FL, Orlando, presented at Experimental Biology Meeting (EB), FL, Orlando, 06 April 2019 - 09 April 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000495951205245&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Current:

2026-2028     Australian Research Council Discovery Project Grant               "Uncovering how molecular motors encode receptor signalling".                        Dr Vaishnavi Ananthanarayanan, Dr Gregory Redpath (Chief Investigator B), Professor Karsten Kruse. AU$788,064

2025-2028    The Health Research Council of New Zealand Project Grant     "Uncovering the connection between serotonin and Lp(a) metabolism".        Professor Sally McCormick, Dr Gregory Redpath (co-Principal Investigator), Professor Peter Shepard, Dr Megan Leask, Professor Michael Williams, Professor Paul Glue. NZ$1,050,000

2024-2027    Royal Society Te Apārangi Marsden Fund Project Grant             "Unravelling the connection between serotonin and Lp(a) catabolism".          Professor Sally McCormick, Dr Gregory Redpath (co-Principal Investigator). NZ$941,000

2023-2026    The Heart Foundation of New Zealand Project Grant                  "Uncovering links between antidepressants and heart disease".                  Professor Sally McCormick, Dr Gregory Redpath (Associate Investigator), Professor Michael Williams. NZ$136,604

Previous:

2024             School of Biomedical Sciences, UNSW Seed Funding Grant          "Understanding psychedelics at the molecular level".                                  Dr Gregory Redpath. $AU5,000

2022             The Lottery Health Foundation of New Zealand Equipment Grant  "Confocal microscopy for biomedical research".                                          Professor Sally McCormick, Dr Gregory Redpath, Professor Peter Dearden. NZ$120,000

2022             School of Biomedical Sciences, UNSW Seed Funding Grant          "Investigating how psychedelics act on serotonin receptors".                      Dr Gregory Redpath. $AU7,498

2019             University of Otago Research Group Project Grant                         "Uncovering how plasminogen receptors control Lp(a) catabolism".              Professor Sally McCormick, Dr Gregory Redpath (Associate Investigator). NZ$63,000

2018-2021    Royal Society Te Apārangi Marsden Fund Project Grant                  "New players in protein recycling".                                                            Professor Sally McCormick, Dr Torsten Kleffmann, Dr Gregory Redpath (Associate Investigator). NZ$957,000

 

2024     Shortlisted for the Journal of Cell Science David Stephens Best Paper of the Year Prize

2022

2022

    Future Leader to Watch, Biology Open

    Featured in Biomedical Picture of the Day, 14 June "Organised Attack"

2018

    Runner-up, Best Postdoctoral Presentation, Australia and New Zealand Society for Cell and Development Cell Biology NSW Research Meeting

2014

    David Walsh Prize for Best Student Presentation, ComBio 2014

2010

    Health Sciences Prestigious Summer Scholarship, University of Otago

2009

    Health Research Council Summer Scholarship, Health Research Council of New Zealand

My Research Supervision

Ph.D. Students

  • Jack Zhang                                                                                                                   (2023- current)
  • David Kim                                                                                                                     (2023- current)
  • Shreya Boby                                                                                                                 (2025- current)

 

Previous Supervision

  Ph.D. Students

  • Halima Siddiqui                                                                                                             (Advisor, University of Otago, NZ, 2019-2023)
  • Manuela Ecker                                                                                                              (UNSW, 2016-2019)

  Honours Students

  • Shreya Boby                                                                                                                  (2023-2024)
  • David Kim                                                                                                                      (2022-2023)
  • Sarah Skerhut                                                                                                                (2022)
  • Haig Vartoukian                                                                                                             (2017)