Dr Nona Farbehi

Dr Nona Farbehi

Senior Lecturer
  • Doctor of Philosophy, GSBmE, University of New South Wales (2014-2018), Supervisor: Prof Richard Harvey & A/Prof Robert Nordon
  • Master of Science, Amir Kabir University of Technology (AUT), Tehran, Iran (2009-2011)
  • Bachelor of Science (Biomedical Engineering) (Honours), SRBIAU, Tehran, Iran (2004-2009), Honours Class I
Engineering
Sch: Biomedical Engineering

Dr Nona Farbehi is a Senior Lecturer at the Graduate School of Biomedical Engineering, UNSW Sydney. She completed her PhD jointly at the Victor Chang Cardiac Research Institute in the laboratory of Prof Richard Harvey and at UNSW in the laboratory of A/Prof Robert Nordon, supported by funding from an International Postgraduate Research Scholarship (IPRS) and Stem Cells Australia (SCA).

Following her doctoral training, Dr Farbehi played a key role in establishing the Garvan–Weizmann Centre for Cellular Genomics (GWCCG), a state-of-the-art national facility providing single-cell and multi-omic technologies to researchers across Australia and internationally. She then undertook postdoctoral training in Prof Joseph Powell’s group from 2020, where her work focused on population-scale stem cell technologies to investigate how common genetic variation shapes cellular phenotypes.

Dr Farbehi joined UNSW Sydney in 2022 and has since established an independent, interdisciplinary research program at the interface of biomedical engineering, genomics, and biomaterials. Her research integrates large-scale single-cell and spatial transcriptomics, advanced bioinformatics, and the design and fabrication of novel biomaterials and microfluidic systems to study cell–material interactions and tissue repair in health and disease.

Location
BABS, E26 Level 1 UNSW Sydney NSW 2052 AUSTRALIA
  • Journal articles | 2026
    Arshadi F; Esfandiari M; Gay R; Enke YL; Farbehi N; Pastras C; Asadnia M, 2026, 'A miniaturized electrochemical biosensor for real-time in vivo potassium monitoring in the inner ear.', Biosens Bioelectron, 298, pp. 118388, http://dx.doi.org/10.1016/j.bios.2026.118388
    Journal articles | 2026
    Haghighattalab M; Maraldo A; Karimi F; Farbehi N; Rnjak‐Kovacina J, 2026, 'Evaluating Flow‐Focused Microfluidic Device Fabrication Techniques for Silk Fibroin Microgel Production', Advanced Materials Technologies, http://dx.doi.org/10.1002/admt.202501402
    Journal articles | 2025
    Farbehi N; Alinejad-Rokny H; Chtanova T; Rnjak-Kovacina J, 2025, 'Spatial and single-cell transcriptomics unravel the complex interplay between the body and medical implants', Cell Biomaterials, 1, http://dx.doi.org/10.1016/j.celbio.2025.100099
    Journal articles | 2024
    Farbehi N; Neavin DR; Cuomo ASE; Studer L; MacArthur DG; Powell JE, 2024, 'Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases', Nature Genetics, 56, pp. 758 - 766, http://dx.doi.org/10.1038/s41588-024-01731-9
    Journal articles | 2024
    Karimi F; Farbehi N; Ziaee F; Lau K; Monfared M; Kordanovski M; Joukhdar H; Molly TG; Nordon R; Kilian KA; Stenzel MH; Lim KS; Rnjak-Kovacina J, 2024, 'Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications', Advanced Functional Materials, 34, http://dx.doi.org/10.1002/adfm.202313354
    Journal articles | 2024
    Karimi F; Farbehi N; Ziaee F; Lau K; Monfared M; Kordanovski M; Joukhdar H; Molly TG; Nordon R; Kilian KA; Stenzel MH; Lim KS; Rnjak‐Kovacina J, 2024, 'Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications (Adv. Funct. Mater. 29/2024)', Advanced Functional Materials, 34, http://dx.doi.org/10.1002/adfm.202470158
    Journal articles | 2024
    Vuong TNAM; Bartolf-Kopp M; Andelovic K; Jungst T; Farbehi N; Wise SG; Hayward C; Stevens MC; Rnjak-Kovacina J, 2024, 'Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries', Advanced Science, 11, http://dx.doi.org/10.1002/advs.202307627
    Journal articles | 2023
    Neavin DR; Steinmann AM; Farbehi N; Chiu HS; Daniszewski MS; Arora H; Bermudez Y; Moutinho C; Chan CL; Bax M; Tyebally M; Gnanasambandapillai V; Lam CE; Nguyen U; Hernández D; Lidgerwood GE; Graham RM; Hewitt AW; Pébay A; Palpant NJ; Powell JE, 2023, 'A village in a dish model system for population-scale hiPSC studies', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-38704-1
    Journal articles | 2022
    Daniszewski M; Senabouth A; Liang HH; Han X; Lidgerwood GE; Hernández D; Sivakumaran P; Clarke JE; Lim SY; Lees JG; Rooney L; Gulluyan L; Souzeau E; Graham SL; Chan CL; Nguyen U; Farbehi N; Gnanasambandapillai V; McCloy RA; Clarke L; Kearns LS; Mackey DA; Craig JE; MacGregor S; Powell JE; Pébay A; Hewitt AW, 2022, 'Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma', Cell Genomics, 2, http://dx.doi.org/10.1016/j.xgen.2022.100142
    Journal articles | 2022
    Janbandhu V; Tallapragada V; Patrick R; Li Y; Abeygunawardena D; Humphreys DT; Martin EMMA; Ward AO; Contreras O; Farbehi N; Yao E; Du J; Dunwoodie SL; Bursac N; Harvey RP, 2022, 'Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction', Cell Stem Cell, 29, pp. 281 - 297.e12, http://dx.doi.org/10.1016/j.stem.2021.10.009
    Journal articles | 2022
    Li J; Lao O; Bruveris FF; Wang L; Chaudry K; Yang Z; Farbehi N; Ng ES; Stanley EG; Harvey RP; Elefanty AG; Nordon RE, 2022, 'Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development', Cell Reports, 40, http://dx.doi.org/10.1016/j.celrep.2022.111339
    Journal articles | 2022
    Senabouth A; Daniszewski M; Lidgerwood GE; Liang HH; Hernández D; Mirzaei M; Keenan SN; Zhang R; Han X; Neavin D; Rooney L; Lopez Sanchez MIG; Gulluyan L; Paulo JA; Clarke L; Kearns LS; Gnanasambandapillai V; Chan CL; Nguyen U; Steinmann AM; McCloy RA; Farbehi N; Gupta VK; Mackey DA; Bylsma G; Verma N; MacGregor S; Watt MJ; Guymer RH; Powell JE; Hewitt AW; Pébay A, 2022, 'Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration', Nature Communications, 13, http://dx.doi.org/10.1038/s41467-022-31707-4
    Journal articles | 2021
    Farbehi N; Janbandhu V; Nordon RE; Harvey RP, 2021, 'Facs enrichment of total interstitial cells and fibroblasts from adult mouse ventricles', Bio Protocol, 11, http://dx.doi.org/10.21769/BioProtoc.4028
    Journal articles | 2021
    Kalra K; Eberhard J; Farbehi N; Chong JJ; Xaymardan M, 2021, 'Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction', Frontiers in Cell and Developmental Biology, 9, http://dx.doi.org/10.3389/fcell.2021.669188
    Journal articles | 2021
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35, http://dx.doi.org/10.1016/j.celrep.2021.108945
    Journal articles | 2019
    Farbehi N; Patrick R; Dorison A; Xaymardan M; Janbandhu V; Wystub-Lis K; Ho JWK; Nordon RE; Harvey RP, 2019, 'Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury', Elife, 8, pp. e43882, http://dx.doi.org/10.7554/eLife.43882
    Journal articles | 2019
    Salomon R; Kaczorowski D; Valdes-Mora F; Nordon RE; Neild A; Farbehi N; Bartonicek N; Gallego-Ortega D, 2019, 'Droplet-based single cell RNAseq tools: A practical guide', Lab on A Chip, 19, pp. 1706 - 1727, http://dx.doi.org/10.1039/c8lc01239c
    Journal articles | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, 'Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', , http://dx.doi.org/10.1101/624890
    Journal articles | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Murphy K; Roden DL; Castillo L; Colino-Sanguino Y; Farbehi N; Conway J; Timpson P; Ormandy CJ; Gallego-Ortega D, 2019, 'Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p022
    Journal articles | 2018
    Farbehi N; Patrick R; Xaymardan M; Harvey R; Nordon R, 2018, 'Large-scale, single cell RNA sequencing defines novel cellular subsets required for cardiac repair', Cytotherapy, 20, pp. S14 - S14, http://dx.doi.org/10.1016/j.jcyt.2018.02.024
    Journal articles | 2017
    Asli N; Xaymardan M; Patrick R; Farbehi N; Cornwell J; Forte E; Waardenberg A; Janbandhu V; Kesteven S; Chandrakanthan V; Malinowska H; Reinhard H; Schofield P; Christ D; Ahmed I; Bouveret R; Srivastava S; Mishra R; Dhawan J; Chong JJH; Nordon R; Macdonald P; Graham R; Feneley M; Harvey R, 2017, 'PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair', , http://dx.doi.org/10.1101/225979
    Journal articles | 2016
    Hassanzadeh-Barforoushi A; Shemesh J; Farbehi N; Asadnia M; Yeoh GH; Harvey RP; Nordon RE; Warkiani ME; Hassanzadehbarforoushi A, 2016, 'A rapid co-culture stamping device for studying intercellular communication', Scientific Reports, 6, pp. 35618, http://dx.doi.org/10.1038/srep35618
  • Preprints | 2025
    Haghighattalab M; Karimi F; Farbehi N; Rnjak-Kovacina J, 2025, Evaluating Flow-Focused Microfluidic Device Fabrication Techniques for Silk Fibroin Microgel Production, http://dx.doi.org/10.1101/2025.02.02.636143
    Preprints | 2025
    Zahedi R; Argha A; Farbehi N; Bakhshayeshi I; Ye Y; Lovell NH; Alinejad-Rokny H, 2025, SemanticST: Spatially Informed Semantic Graph Learning for Clustering, Integration, and Scalable Analysis of Spatial Transcriptomics, http://dx.doi.org/10.48550/arxiv.2506.11491
    Conference Papers | 2024
    Karimi F; Farbehi N; Haghighattalab M; Lau K; Kordanovski M; Lim K; Rnjak-Kovacina J, 2024, 'Photocrosslinked Silk Fibroin Microgels And Microgel Scaffolds For Biomedical Applications', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, WA, Seattle, pp. S27 - S28, presented at 7th TERMIS World Congress, WA, Seattle, 25 June 2024 - 28 June 2024
    Preprints | 2024
    Liang Y; Abedini S; Farbehi N; Alinejad-Rokny H, 2024, How chromatin interactions shed light on interpreting non-coding genomic variants: opportunities and future direc-tions, http://dx.doi.org/10.48550/arxiv.2411.17956
    Preprints | 2024
    Nazeen S; Wang X; Zielinski D; Lam I; Hallacli E; Xu P; Ethier E; Strom R; Zanella CA; Nithianandam V; Ritter D; Henderson A; Saurat N; Afroz J; Nutter-Upham A; Benyamini H; Copty J; Ravishankar S; Morrow A; Mitchel J; Neavin D; Gupta R; Farbehi N; Grundman J; Myers RH; Scherzer CR; Trojanowski JQ; Van Deerlin VM; Cooper AA; Lee EB; Erlich Y; Lindquist S; Peng J; Geschwind DH; Powell J; Studer L; Feany MB; Sunyaev SR; Khurana V, 2024, Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies., http://dx.doi.org/10.1101/2024.03.03.583145
    Preprints | 2021
    Daniszewski M; Senabouth A; Liang H; Han X; Lidgerwood G; Hernández D; Sivakumaran P; Clarke J; Lim S; Lees J; Rooney L; Gulluyan L; Souzeau E; Graham S; Chan C-L; Nguyen U; Farbehi N; Gnanasambandapillai V; McCloy R; Clarke L; Kearns L; Mackey D; Craig J; MacGregor S; Powell J; Pébay A; Hewitt A, 2021, Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma, http://dx.doi.org/10.1101/2021.07.14.452417
    Preprints | 2021
    Senabouth A; Daniszewski M; Lidgerwood G; Liang H; Hernández D; Mirzaei M; Zhang R; Han X; Neavin D; Rooney L; Sanchez IL; Gulluyan L; Paulo J; Clarke L; Kearns L; Gnanasambandapillai V; Chan C-L; Nguyen U; Steinmann A; Zekanovic R; Farbehi N; Gupta V; Mackey D; Bylsma G; Verma N; MacGregor S; Guymer R; Powell J; Hewitt A; Pébay A, 2021, Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration, http://dx.doi.org/10.1101/2021.08.19.457044
    Preprints | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype, http://dx.doi.org/10.1101/624890
    Conference Abstracts | 2018
    Farbehi N; Patrick R; Xaymardan M; Harvey R; Nordon R, 2018, 'LARGE-SCALE, SINGLE CELL RNA SEQUENCING DEFINES NOVEL CELLULAR SUBSETS REQUIRED FOR CARDIAC REPAIR', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 20, pp. S14 - S14, http://dx.doi.org/10.1016/j.jcyt.2018.02.024
    Preprints | 2017
    Asli N; Xaymardan M; Patrick R; Farbehi N; Cornwell J; Forte E; Waardenberg A; Janbandhu V; Kesteven S; Chandrakanthan V; Malinowska H; Reinhard H; Schofield P; Christ D; Ahmed I; Bouveret R; Srivastava S; Mishra R; Dhawan J; Chong JJH; Nordon R; Macdonald P; Graham R; Feneley M; Harvey R, 2017, PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair, http://dx.doi.org/10.1101/225979
    Conference Abstracts | 2017
    Farbehi N; Patrick R; Xaymardan M; Harvey RP; Nordon R, 2017, 'HIGH THROUGHPUT SINGLE-CELL MRNA SEQUENCING REVEALS CELLULAR HETEROGENEITY IN CARDIAC MSCS AFTER MYOCARDIAL INFARCTION (MI)', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Technol Sydney, Sydney, Vol. 20, presented at Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), AUSTRALIA, Univ Technol Sydney, Sydney, 24 May 2017 - 26 May 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426528300056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2016
    Hassanzadehbarforoushi A; Shemesh J; Farbehi N; Asadnia M; Yeoh G; Nordon R; Ebrahimi warkiani M, 2016, 'A RAPID MICROFLUIDIC STAMPING DEVICE FOR STUDYING CARDIAC STEM CELLS AND ENDOTHELIAL CELLS CO-CULTURE', in Proceedings MicroTAS 2016, Dublin, Republic of Ireland, presented at The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Republic of Ireland, 09 October 2016 - 13 October 2016
    Preprints |
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes SR; Sikta N; O'Donoghue SI; Cox TR; Timpson P; Ormandy CJ; Gallego Ortega D, Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, http://dx.doi.org/10.2139/ssrn.3634808

  • CI in Australia-Germany Joint Research Cooperation Scheme (DAAD), ‘Utilizing Advanced Scaffold Fabrication Technologies for Functional Cardiac Implants ’, 2025-2027
  • CI in UNSW Faculty of Engineering Infrastructure Fund ‘Mechanical testing equipment for soft and anisotropic materials’, $270K, 2023
  • CI in NSW Health Cardiovascular Research Capacity Program Collaborative Grants - ‘Engineering next generation aortic valve replacement materials’, $950K, 2023-2024
  • AI in NHMRC ID2000615, ‘Crossing a frontier in cardiac fibrosis: a single-cell multiomics approach to understanding fibroblast agency in models of heart’, 2020

 

  • University of New South Wales International Postgraduate Research Scholarship, Sydney, Australia, 2014-2017.
  • ASSCR & NSCFA travel award, Lorne, Australia, 2014
  • ASSCR & NSCFA travel award, Hunter Valley, Australia, 2015
  • UNSW Student Travel Scholarship, Keystone Conference, Snowbird, USA, 2016
  • The 17th Victor Chang International Symposium, best PhD poster award-Third place, Sydney, Australia, 2016
  • ASSCR meeting, student travel award, Perth, Australia, 2016
  • Stem Cells Australia (SCA) Retreat, best poster prize and free registration of ASSCR 2018, Gold Coast, Australia, 2017.
  • 25th St Vincent’s Research Symposium, The runner-up poster prize, Sydney, Australia, 2017
  • ASSCR/AGCTS annual meeting, student travel award, Sydney, Australia, 2017
  • Sydney Cardiovascular Symposium, best poster prize (& flash talk), Sydney, Australia, 2017
  • ASSCR & NSCFA, travel award, Melbourne, Australia, 2018.
  • Nominated for the Malcolm Chaikin Prize as the best PhD thesis in the Biomedical Engineering Graduate Research School at UNSW, 2018.
  • ASSCR/AGCTS annual meeting, travel award, Melbourne, Australia, 2022
  • Top 3 Rising Stars at ASSCR (2022)
  • NSW Cardiovascular Research Network 2023 Professional Development Award, National Heart Foundation (2023) 
  • ASAP/MJFF Care and Carer award 2023, MJFF (2023) 
  • 10X Founder, New Wave top 10 innovator (2025)
  • 10X Founder, New Wave Faculty of Engineering and Faculty of Health awards (2025)

  • Biomedical Engineering
  • Regenerative Medicine (Stem Cells and Tissue Engineering)
  • Microfluidic Devices
  • Cardiac disease
  • Single cell genomics
  • CRISPR interference and Perturb-seq
  • Biomaterials

My Research Supervision

PhD candidates: 

Mahsa Haghighattalab
Trinh (Judy) Ho
Renuka Gupta
Amin Maghsoudi 

Master students:

Harimas Lianggara
Xinsong Lu
Amal Ibrahim

Honours students:

Pooja Parashar
Jade Yuen
Jiyana Thankam
Willson Blesstian
Robert Brady